If the under-eye area is your biggest bugbear, such as dark circles, fine lines, or that tired look that no amount of sleep or skincare seems to fix, then polynucleotide injections might just be your new favourite treatment.
At Ametrine, we’re seeing more and more clients choose polynucleotides as a natural, gentle way to restore life to the delicate skin under the eyes. Let’s break down why this regenerative injectable is having a moment beyond the social media hypet, and whether it could be the right fit for you.
Why is the under-eye area so tricky?
The skin under your eyes is the thinnest on your face and one of the first places to show signs of ageing, dehydration, or stress. Volume loss, pigmentation, and reduced collagen all play a part in that ‘tired’ or sunken look.
The process of ageing begins in the fatty layers of the skin, and under the eyes, the fat layers that sit close to the surface are scarce to begin with. The sin under the yes is constantly moving with facial expression, and as a result of the lack of structural support from the fat and movable skin, the area loses its firmness rapidly. In addition to surface-layer ageing, the skull also changes; the eye socket gradually widens, resulting in even less support for this already under-supported tissue. The result can be hollows, also known as tear troughs, lines, or wrinkles, making the region look dull and shadowed.
Traditional fillers can sometimes be too much for this fragile area, especially in situations where the skin is a problem, and instead of looking smooth and bright the area can look puffy, and sometimes compromise the delicate lymphatic drainage under the eye. That’s where polynucleotides come in.
What are polynucleotide injections—and why are they different?
Polynucleotides are made from fragments of trout DNA (don’t worry, they’re highly purified and safe) and work with your skin’s natural processes. Rather than simply filling or masking the problem, they regenerate the tissue from within.
They boost fibroblast activity, stimulate collagen and elastin, and improve microcirculation. The results? You get smoother, firmer, brighter skin that looks like you…just fresher.
They’re especially well-suited to under-eyes because they hydrate, firm and heal without the risk of puffiness or unnatural volume.
What can polynucleotide eye treatments help with?
At Ametrine, we use polynucleotides under the eyes to target:
- Fine lines and crepey texture
- Dark circles caused by thin or dehydrated skin
- Tired, dull under-eyes
- Mild under-eye hollows
- General skin laxity
- Facial redness or rosacea
For more info on who’s best suited to this treatment, have a peek at our blog: Who Can Benefit from Polynucleotide Injections?
What to expect during treatment
The process is quick; we’ll cleanse the area, apply numbing cream if needed, and gently inject the polynucleotide solution just under the skin.
You might feel a slight scratch or pinch when we use either cannula or mesotherapy. The product can have a sting when injected, and this is because the product is highly purified with no lidocaine in it (like dermal filler). Still, most people find the treatment very tolerable—and it only takes around 15–20 minutes.
And afterwards?
You may notice a bit of swelling or tiny injection bumps straight after treatment (totally normal), but these usually settle within 24–48 hours. You can find a full breakdown of post-treatment care and what to expect in our blog:
What to Expect After Polynucleotide Injections: Recovery & Results Timeline
Results tend to build gradually as your skin regenerates, expect to see real improvements after 2–3 sessions spaced a few weeks apart, with optimal results showing after 6–8 weeks.
How does it compare to other treatments like Profhilo?
While both are fantastic skin boosters, they work a little differently. Profhilo uses hyaluronic acid to hydrate and firm the skin, whereas polynucleotides actually help your skin repair and regenerate itself at a cellular level.
If you’re torn between the two, read our comparison blog.
Polynucleotides vs Profhilo: What’s the Difference & Which One is Right for You?
Final thoughts from the clinic
At Ametrine, our vibe is always calm, uplifting, and inclusive. No clinical vibes, no pressure, just honest advice and treatments that work for you.
If you’re curious about brightening up your under-eyes without going down the filler route, book a consultation and let’s chat about whether polynucleotides are the right fit for your skin goals.
We’ll take the time to assess your skin, talk through the options, and make sure you feel fully informed and relaxed at every step.
