Your guide to recovery, renewal, and radiant results
Polynucleotide injections have become one of our favourite ways to regenerate tired, stressed, or ageing skin — and for good reason.
At Ametrine, we love them for their ability to work with your skin, not against it. They stimulate repair, boost hydration, and restore balance from within…leaving you with a complexion that looks fresh, luminous, and quietly confident.
If you’re considering trying them, you might be wondering: What actually happens after treatment?
Let’s walk through what to expect, from the first few hours to the months ahead, so you can feel calm, informed, and excited about your skin’s journey.
Immediately After Treatment
Right after your appointment, you may notice small bumps or a light swelling at the injection sites. These can look a little like insect bites, completely normal, and a sign your skin is responding just as it should.
They usually settle within a few hours, though occasionally it can take 24–48 hours for the area to fully calm.
You might also experience:
- Mild redness or warmth
- Slight tenderness when touched
- A gentle tingling sensation
We recommend giving your skin time to breathe. Avoid makeup, heat, or exercise for the next 24 hours…think of it as downtime for your skin while it quietly begins its rejuvenation work beneath the surface.
The First Week: Quiet Renewal
During the first week, subtle changes are already underway. Polynucleotides kickstart cell renewal and healing, but unlike some treatments, there’s no peeling, flaking, or visible downtime.
You might notice your skin feels slightly tighter or drier for a few days. That’s perfectly normal. Keep your skincare simple, gentle, and hydrating…think soothing moisturisers and daily SPF (your future skin will thank you).
If you’re unsure what to use, we’ll always walk you through a personalised aftercare plan during your appointment.
Weeks 2–4: The Glow Appears ✨
This is when most clients begin to see what we call the “Polynucleotide glow.”
Your skin starts to look smoother, more even in tone, and naturally luminous, the kind of healthy radiance that’s hard to describe but easy to recognise.
You may notice:
- A brighter, more balanced complexion
- Plumper, more hydrated skin
- Fine lines softening, and texture evening out
Remember, these results develop gradually. Polynucleotides don’t “fill” or “freeze”…they regenerate. The true transformation unfolds gently over time.
After Multiple Sessions: Deep Regeneration
For most people, the best results come after a course of 2–4 treatments, spaced a few weeks apart.
Each session builds upon the last, encouraging your skin to continue repairing, firming, and strengthening itself. Think of it as teaching your skin how to behave like its younger self again – supported, hydrated, and resilient.
Over time, clients love how Polynucleotides help to:
- Reduce fine lines and improve elasticity
- Minimise acne scarring and uneven tone
- Revive tired, dull, or stressed skin
- Strengthen the skin barrier for long-term radiance
It’s transformation…but from the inside out.
How Polynucleotides Compare
If you’re still deciding between treatments like Profhilo or Polynucleotides, you’re not alone, it’s a common conversation in clinic.
Both are regenerative, but they work in slightly different ways. Profhilo delivers deep hydration, while Polynucleotides focus on healing, structure, and regeneration.
You can read our full comparison here: Polynucleotides vs Profhilo: What’s the Difference?
A Thought from Our Team 🌿
Every face is different, and so is every healing journey.
At Ametrine, we don’t believe in one-size-fits-all skincare. We take the time to understand your skin, your lifestyle, and what feeling confident really looks like for you.
Our clinic isn’t a place of perfection or pressure – it’s a calm, supportive space where your skin can rest, recover, and return to its best.
If you’re ready to explore regenerative treatments that feel as good as they look, we’d love to welcome you in.
✨ Book your consultation or start your free online assessment to discover if Polynucleotides could be your skin’s next chapter.
