When it comes to modern skin rejuvenation, few treatments have created as much buzz as Polynucleotides and Profhilo.
Both sit under the umbrella of regenerative injectable, treatments designed not to change how you look, but to help your skin function better. They support hydration, healing, and collagen renewal from within.
But how do you know which one your skin truly needs?
Let’s take a calm, science-backed look, without the jargon or hype, at what sets them apart and how each can support your skin’s natural rhythm.
What Are They – and How Do They Work?
Profhilo: Deep Hydration and Radiance
Often described as an injectable moisturiser, Profhilo is made up of one of the highest concentrations of pure hyaluronic acid on the market.
Rather than simply filling or lifting, it works by slowly releasing hydration deep into the skin, stimulating collagen and elastin production along the way. The result is skin that feels smoother, firmer, and deeply nourished…that signature, healthy “glow from within.”
It’s a beautiful option if your skin feels dull, dry, or lacks elasticity.
Polynucleotides: Skin Regeneration from the Inside Out
Polynucleotides are a completely different kind of injectable treatment. Derived from purified DNA fragments (often from salmon or trout – yes, really!), they act as messengers that help your cells repair, regenerate, and renew.
At Ametrine, we use Plinest Polynucleotides, a clinically proven brand with exceptional results for improving texture, healing, and resilience.
Think of it this way: Profhilo hydrates the skin you have. Polynucleotides restore the skin you’ve lost.
Who Might Each Treatment Suit Best?
Profhilo works beautifully for:
- Deep, long-lasting hydration
- Boosting elasticity and firmness
- Dull or tired complexions
- Face, neck, and décolletage rejuvenation
Polynucleotides are ideal for:
- Supporting tissue repair and cell regeneration
- Reducing inflammation and improving healing
- Improving under-eye texture and brightness
- Strengthening skin affected by scarring or pigmentation
So… Which One Should You Choose?
It really depends on your goals.
If your main concern is dehydration or you want an instant, luminous boost, Profhilo delivers that fast, glassy glow.
But if you’re working with more complex skin concerns, such as post-acne texture, pigmentation, or early signs of ageing, Polynucleotides are often the more restorative choice.
At Ametrine, we often use both as part of a regenerative skin journey – layering them strategically over time for even greater impact.
The Treatment Experience
Both treatments are injectable, but they’re performed differently.
Profhilo follows a standard five-point injection pattern on each side of the face. It’s quick, efficient, and perfect for those who prefer a minimal-appointment approach.
Polynucleotides, on the other hand, are more bespoke. We tailor each session depending on your skin, targeting under the eyes, around the mouth, or across the cheeks where needed most. The process is still gentle and comfortable, just more personalised.
What About Downtime?
Both treatments have minimal downtime. You might notice small bumps or light redness at the injection points, but these usually settle within a few hours.
Polynucleotides can take a little longer to reveal their full effect, as they’re working deep within the skin’s structure, but that patience is rewarded with results that keep improving for months.
What Kind of Results Can You Expect?
Profhilo gives you that signature glow — plumper, smoother, more hydrated skin in just a few weeks. It’s perfect before events, or when you want a quick refresh that feels light and natural.
Polynucleotides deliver a slower transformation, improving tone, texture, and firmness from within. Over time, you’ll notice softer lines, improved elasticity, and a general sense that your skin looks healthier.
It’s regeneration — not correction.
A Note from Dr Bryony Elder
There’s no one-size-fits-all when it comes to injectables…and that’s the beauty of this work.
At Ametrine, every treatment plan begins with a conversation. We’ll look at your skin’s story, your goals, and your lifestyle to design something that truly fits you. Sometimes that’s Profhilo. Sometimes it’s Polynucleotides. Sometimes, it’s both.
The aim is always the same: natural, confident, radiant skin, achieved with care, not compromise. 🌿
Ready to Begin?
If you’d like to explore Polynucleotides, Profhilo, or a custom plan designed around your skin, we’d love to guide you.
✨ Start with our free online skin assessment or book your consultation at our Newcastle clinic.
Because true rejuvenation starts with understanding your skin… and giving it exactly what it needs.
